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Phenotypes Associated with This Genotype
Genotype
MGI:5882505
Allelic
Composition
Chattm2(cre)Lowl/Chat+
Cpeb2tm1.1Yshu/Cpeb2tm1.1Yshu
Genetic
Background
involves: C57BL/6 * C57BL/6J * C57BL/6NJ * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm2(cre)Lowl mutation (4 available); any Chat mutation (13 available)
Cpeb2tm1.1Yshu mutation (0 available); any Cpeb2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• whole-body plethysmography revealed respiratory defects similar to those observed in Cpeb2tm1.2Yshu homozygotes but with wide individual variation in severity
• however, tidal volume is normal at P1
• aberrant respiration patterns at P1
• reduced respiratory frequency at P1
• increased apneic episodes at P1
• inhalation of nebulized tiotropium, an anticholinergic bronchodilator, reduces apnea frequency to wild-type levels
• significantly increased methacholine-induced airway reactivity in adult mice

nervous system
• increased pulmonary acetylcholine level at P1

homeostasis/metabolism
• increased pulmonary acetylcholine level at P1
• increased choline acetyltransferase (ChAT) expression in the dorsal motor nucleus of vagus (DMNV)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory