Phenotypes Associated with This Genotype

Genotype
MGI:5882505

• Allelic Composition: Chat^tm2(cre)Lowl/Chat⁺; Cpeb2^tm1.1Yshu/Cpeb2^tm1.1Yshu
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NJ * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal whole-body plethysmography ( J:237513 )

• whole-body plethysmography revealed respiratory defects similar to those observed in Cpeb2^tm1.2Yshu homozygotes but with wide individual variation in severity

• however, tidal volume is normal at P1

abnormal breathing pattern ( J:237513 )

• aberrant respiration patterns at P1

decreased pulmonary respiratory rate ( J:237513 )

• reduced respiratory frequency at P1

apnea ( J:237513 )

• increased apneic episodes at P1

• inhalation of nebulized tiotropium, an anticholinergic bronchodilator, reduces apnea frequency to wild-type levels

increased airway responsiveness ( J:237513 )

• significantly increased methacholine-induced airway reactivity in adult mice

homeostasis/metabolism

increased acetylcholine level ( J:237513 )

• increased pulmonary acetylcholine level at P1

increased brain choline acetyltransferase activity ( J:237513 )

• increased choline acetyltransferase (ChAT) expression in the dorsal motor nucleus of vagus (DMNV)