Phenotypes Associated with This Genotype

Genotype
MGI:5881925

• Allelic Composition: Apc^Min/Apc⁺; Arhgef4^tm1Taki/Arhgef4^tm1Taki; Spata13^tm1Taki/Spata13^tm1Taki
• Genetic Background: B6J.Cg-Arhgef4^tm1Taki Spata13^tm1Taki Apc^Min

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased intestinal adenoma incidence ( J:157023 )

• mice develop only a few small adenomas (polyps) by 4 months of age

abnormal tumor pathology ( J:157023 )

• mice show loss of the wild-type Apc allele in the small adenomas formed

• Rac1 and Cdc42 signaling appears to be reduced

abnormal tumor vascularization ( J:157023 )

• the density of microvessels within adenomas is significantly lower than that in Apc^Min heterozygotes

• however, tumor-associated macrophages are recruited to adenomas and release vascular endothelial growth factor normally

decreased tumor growth/size ( J:157023 )

• mice develop only a few small adenomas (polyps) by 4 months of age

cardiovascular system

abnormal tumor vascularization ( J:157023 )

• the density of microvessels within adenomas is significantly lower than that in Apc^Min heterozygotes

• however, tumor-associated macrophages are recruited to adenomas and release vascular endothelial growth factor normally

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:157023 )

• treatment of mice with zoledronic acid (a specific inhibitor of MMP9) for 6 weeks fails to result in further suppression of adenoma formation, unlike in Apc^Min heterozygotes

digestive/alimentary system

decreased intestinal adenoma incidence ( J:157023 )

• mice develop only a few small adenomas (polyps) by 4 months of age