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Phenotypes Associated with This Genotype
Genotype
MGI:5829832
Allelic
Composition
Nkx2-5tm2.1Mwc/Nkx2-5+
Genetic
Background
B6J.Cg-Nkx2-5tm2.1Mwc/Mwc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm2.1Mwc mutation (0 available); any Nkx2-5 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• right ventricular dysmorphism with a shift to the base, rounded apex, and misalignment relative to the left ventricle
• reduction in node size
• in 71% of heterozgyous adults
• distinct from heterozygotes with a proline substitution, these heterozygotes have decreased left ventrical mass
• distinct from heterozygotes with a proline substitution, these heterozygotes have decreased left ventricular stroke volume
• heterozygotes have a signficant decrease in right ventricle ejection fraction as well as a decrease in left ventricular stroke volume and end diastolic volume
• left ventricle shows decreased end diastolic volume, stroke volume, and heart mass
• under homeostatic nonanesthetized conditions there is increased PQ and QRS and a small tendency for decreased ST intervals, and occasional arrhythmic episodes were observed with highly irregular PR intervals
• wide variability in PR intervals in nonanesthetized electrocardiograms, with some showing increased PR
• wide variability in QRS intervals in nonanesthetized electrocardiograms, with some showing increased QRS
• widened ST intervals
• small tendency for decreased ST interval

muscle
• reduction in node size
• heterozygotes have a signficant decrease in right ventricle ejection fraction as well as a decrease in left ventricular stroke volume and end diastolic volume


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory