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Phenotypes Associated with This Genotype
Genotype
MGI:5829208
Allelic
Composition		 Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Tg(Ins2-Akt1*)3Mbb/0
Genetic
Background		 B6.Cg-Rps6kb2tm1Gtho Tg(Ins2-Akt1*)3Mbb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb2tm1Gtho mutation (0 available); any Rps6kb2 mutation (21 available)
Tg(Ins2-Akt1*)3Mbb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased insulinoma incidence ( J:144599 )
• mice develop insulinomas with a 26% penetrance between 10 and 20 months of age

neoplasm
increased insulinoma incidence ( J:144599 )
• mice develop insulinomas with a 26% penetrance between 10 and 20 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory