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Phenotypes Associated with This Genotype
Genotype
MGI:5829203
Allelic
Composition		 Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Rps6kb2tm1Gtho/Rps6kb2tm1Gtho
Tg(Ins2-Akt1*)3Mbb/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb1tm1Gtho mutation (1 available); any Rps6kb1 mutation (55 available)
Rps6kb2tm1Gtho mutation (0 available); any Rps6kb2 mutation (22 available)
Tg(Ins2-Akt1*)3Mbb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell morphology ( J:144599 )
• pancreatic beta cells are 4-fold larger than wild-type cells

neoplasm
neoplasm ( J:144599 )
N
• mice do not develop insulinomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory