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Phenotypes Associated with This Genotype
Genotype
MGI:5825360
Allelic
Composition		 Pax5tm3Mbu/Pax5+
Tcf3tm1(PBX1)Mlc/Tcf3+
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Pax5tm3Mbu mutation (1 available); any Pax5 mutation (40 available)
Tcf3tm1(PBX1)Mlc mutation (0 available); any Tcf3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell acute lymphoblastic leukemia incidence ( J:226241 )
• mice exhibit increased penetrance and accelerated acute leukemia development compared to single Tcf3tm1(PBX1)Mlc conditional mutants

hematopoietic system
decreased immature B cell number ( J:226241 )
• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation
abnormal pro-B cell morphology ( J:226241 )
• preleukemic mice show expansion of GFP+ progenitor cells of the Lin-CD19+CD43+ fractions at younger ages compared to single Tcf3tm1(PBX1)Mlc conditional mutants, indicating accelerated preleukemic progenitor B cell expansion
arrested B cell differentiation ( J:226241 )
• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation

immune system
decreased immature B cell number ( J:226241 )
• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation
abnormal pro-B cell morphology ( J:226241 )
• preleukemic mice show expansion of GFP+ progenitor cells of the Lin-CD19+CD43+ fractions at younger ages compared to single Tcf3tm1(PBX1)Mlc conditional mutants, indicating accelerated preleukemic progenitor B cell expansion
arrested B cell differentiation ( J:226241 )
• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory