Phenotypes Associated with This Genotype

Genotype
MGI:5825065

• Allelic Composition: Cdkn1c^tm1Sje/Cdkn1c⁺
• Genetic Background: involves: 129S2/SvHsd * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:232408 )

• embryos with the maternally inherited allele die neonatally

adipose tissue

abnormal brown adipose tissue morphology ( J:232408 )

• expression of brown adipose development and function genes are altered in embryos with the maternally inherited allele, indicating compromised brown adipose tissue development

• interscapular brown adipose tissue shows disorganized morphology with large areas of lipid in E18.5 fetuses with the materanally inherited allele

• mitochondrial DNA content of interscapular brown adipose tissue in embryos with the maternally inherited allele is 40% less than the wild-type level

decreased brown adipose tissue amount ( J:232408 )

• E18.5 embryos with the maternally inherited allele have poorly discernable interscapular brown adipose tissue depots lacking the characteristic butterfly shape normally seen at this stage

abnormal interscapular fat pad morphology ( J:232408 )

• E18.5 embryos with the maternally inherited allele have poorly discernable interscapular brown adipose tissue depots lacking the characteristic butterfly shape normally seen at this stage

• interscapular brown adipose tissue shows disorganized morphology with large areas of lipid at E18.5

• mitochondrial DNA content of interscapular brown adipose tissue is 40% less than the wild-type level