Phenotypes Associated with This Genotype

Genotype
MGI:5825029

• Allelic Composition: Slc6a8^tm1.1Lbar/Y; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:238578 )

♂ • mice show impaired performance in the object recognition test, indicating impaired declarative memory, showing both a defect in short-term (1-hour) and long-term (24-hour) memory at P180

impaired long-term object recognition memory ( J:238578 )

♂ • mice show a defect in long-term (24-hour) memory at P180

impaired short-term object recognition memory ( J:238578 )

♂ • mice show a defect in short-term (1-hour) memory at P180

abnormal spatial working memory ( J:238578 )

♂ • mice show bout a 10% lower alternation rate in the Y maze, indicating impaired working memory

cellular

abnormal neuron proliferation ( J:238578 )

♂ • the number of Ki67-positive cells in the dentate gyrus is decreased at P180, indicating reduced neurogenesis

homeostasis/metabolism

decreased creatine level ( J:238578 )

♂ • creatine levels in the brain are decreased

nervous system

abnormal neuron proliferation ( J:238578 )

♂ • the number of Ki67-positive cells in the dentate gyrus is decreased at P180, indicating reduced neurogenesis

abnormal dentate gyrus morphology ( J:238578 )

♂ • the number of Ki67-positive cells in the dentate gyrus is decreased at P180, indicating reduced neurogenesis