Phenotypes Associated with This Genotype

Genotype
MGI:5824254

• Allelic Composition: Tg(Erbb2-Erbb2*V664E)#Led/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:62441 )

♀ • some tumors are micropapillary adenocarcinomas

increased mammary gland tumor incidence in breeding females ( J:62441 )

♀ • the fourth inguinal mammary gland shows an average of 4-5 small tumor foci spread throughout the gland

♀ • several multiparous females develop palpable tumors, with an average age of onset of 14.5 months

♀ • tumors show multiple morphologies with some tumors composed of solid nests of cells and some in which nests of micropapillary neoplasms are formed and surrounded by a dense connective tissue with necrosis within the centers

♀ • masses consisting of dysplastic glands and squamous epithelium are seen

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:62441 )

♀ • after 3 rounds of pregnancy, the mammary gland shows an inability to involute and fails to regress even after a few months

abnormal mammary gland lobule morphology ( J:62441 )

♀ • adult virgin mammary gland show precocious lobuloalveolar development and dilation of primary and secondary ducts, with some regions showing more extensive proliferation

increased mammary adenocarcinoma incidence ( J:62441 )

♀ • some tumors are micropapillary adenocarcinomas

increased mammary gland tumor incidence in breeding females ( J:62441 )

♀ • the fourth inguinal mammary gland shows an average of 4-5 small tumor foci spread throughout the gland

♀ • several multiparous females develop palpable tumors, with an average age of onset of 14.5 months

♀ • tumors show multiple morphologies with some tumors composed of solid nests of cells and some in which nests of micropapillary neoplasms are formed and surrounded by a dense connective tissue with necrosis within the centers

♀ • masses consisting of dysplastic glands and squamous epithelium are seen

mammary gland hyperplasia ( J:62441 )

♀

abnormal mammary gland physiology ( J:62441 )

♀ • the mammary gland produces large amounts of laminar keratin

abnormal lactation ( J:62441 )

♀ • in multiparous mice, rather than reverting to a near virgin state after pregnancy, the gland continues to produce milk proteins and lipids long after weaning

integument

abnormal involution of the mammary gland ( J:62441 )

♀ • after 3 rounds of pregnancy, the mammary gland shows an inability to involute and fails to regress even after a few months

abnormal mammary gland lobule morphology ( J:62441 )

♀ • adult virgin mammary gland show precocious lobuloalveolar development and dilation of primary and secondary ducts, with some regions showing more extensive proliferation

increased mammary adenocarcinoma incidence ( J:62441 )

♀ • some tumors are micropapillary adenocarcinomas

increased mammary gland tumor incidence in breeding females ( J:62441 )

♀ • the fourth inguinal mammary gland shows an average of 4-5 small tumor foci spread throughout the gland

♀ • several multiparous females develop palpable tumors, with an average age of onset of 14.5 months

♀ • tumors show multiple morphologies with some tumors composed of solid nests of cells and some in which nests of micropapillary neoplasms are formed and surrounded by a dense connective tissue with necrosis within the centers

♀ • masses consisting of dysplastic glands and squamous epithelium are seen

mammary gland hyperplasia ( J:62441 )

♀

abnormal mammary gland physiology ( J:62441 )

♀ • the mammary gland produces large amounts of laminar keratin

abnormal lactation ( J:62441 )

♀ • in multiparous mice, rather than reverting to a near virgin state after pregnancy, the gland continues to produce milk proteins and lipids long after weaning

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:62441