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Phenotypes Associated with This Genotype
Genotype
MGI:5823281
Allelic
Composition		 Cacna1dtm1Jst/Cacna1dtm1Jst
Kcnj5tm1Clph/Kcnj5tm1Clph
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1dtm1Jst mutation (0 available); any Cacna1d mutation (117 available)
Kcnj5tm1Clph mutation (1 available); any Kcnj5 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:230439 )
N
• mice exhibit amelioration of sinoatrial node dysfunction, prevention of tachycardia-bradycardia syndrome, and normalization of atrioventricular (AV) impulse conduction when compared to single Cacna1d homozygotes indicating rescue of sick sinus syndrome and heart block
• the IKACh (Kcnj5) peptide blocker tertiapin-Q does not affect heart rate
• no atrial fibrillation or atrial tachycardia is seen after intracardiac atrial stimulation and atrial myocytes show normal action potential duration

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory