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Phenotypes Associated with This Genotype
Genotype
MGI:5819195
Allelic
Composition		 Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep63Gt(EUCE0251h11)Hmgu mutation (0 available); any Cep63 mutation (42 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:224364 )
N
• complete rescue of brain size and of cortical thickness, as determined in motor and visual cortex sections at P60
• complete rescue of apoptosis in the cortex at E14.5, as shown by TUNEL staining
• reduction of SOX2-positive neural progenitor cell (NPC) number is rescued; however, majority of the rescued NPCs are misplaced from the ventricular zone (extra-VZ)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory