Phenotypes Associated with This Genotype

Genotype
MGI:5817989

• Allelic Composition: Bap1^em3Test/Bap1⁺
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased ovary tumor incidence ( J:231692 )

♀ • high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

♀

increased incidence of tumors by chemical induction ( J:231692 )

• 71% of mice chronically injected intraperitoneally with crocidolite asbestos fibers develop peritoneal malignant mesotheliomas compared to 35% of wild-type mice

• asbestos-induced malignant mesotheliomas are larger and more aggressive than in wild-type mice, often with invasion to the pancreas, liver and/or intestinal smooth muscle

• mice injected with asbestos succumb to disease earlier than wild-type mice, with a median survival of 46 weeks compared to 60 weeks in wild-type mice

increased skin tumor incidence ( J:231692 )

• moderate incidence of spindle cell tumor of the skin

increased lymphoma incidence ( J:231692 )

• low incidence of lymphoma

increased lung carcinoma incidence ( J:231692 )

• low incidence of lung carcinoma

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased ovary tumor incidence ( J:231692 )

♀ • high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

♀

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:231692 )

• 71% of mice chronically injected intraperitoneally with crocidolite asbestos fibers develop peritoneal malignant mesotheliomas compared to 35% of wild-type mice

• asbestos-induced malignant mesotheliomas are larger and more aggressive than in wild-type mice, often with invasion to the pancreas, liver and/or intestinal smooth muscle

• mice injected with asbestos succumb to disease earlier than wild-type mice, with a median survival of 46 weeks compared to 60 weeks in wild-type mice

integument

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased skin tumor incidence ( J:231692 )

• moderate incidence of spindle cell tumor of the skin

reproductive system

increased ovary tumor incidence ( J:231692 )

♀ • high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

♀

respiratory system

increased lung carcinoma incidence ( J:231692 )

• low incidence of lung carcinoma