Phenotypes for Rai1 Slc17a6 MGI:5817637 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rai1^tm2.1Luo/Rai1^tm2.1Luo Slc17a6^tm2(cre)Lowl/?
Genetic Background	either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1^tm2.1Luo mutation (1 available); any Rai1 mutation (72 available)
Slc17a6^tm2(cre)Lowl mutation (3 available); any Slc17a6 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal associative learning ( J:237687 )

impaired contextual conditioning behavior ( J:237687 )

• decreased freezing behavior in contextual recall in trace fear-conditioning task

impaired cued conditioning behavior ( J:237687 )

• decreased freezing behavior in cued recall

impaired coordination ( J:237687 )

• increased time required to descend in pole test

• increased latency to fall in wire hang test

growth/size/body

obese ( J:237687 )

• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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