Phenotypes for Il10 Rreb1 MGI:5817433 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Il10^tm1Cgn/Il10^tm1Cgn Rreb1^Sao/Rreb1^Sao
Genetic Background	NOD.Cg-Il10^tm1Cgn Rreb1^Sao

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10^tm1Cgn mutation (15 available); any Il10 mutation (43 available)
Rreb1^Sao mutation (0 available); any Rreb1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:237902 )

• by 3 weeks of age homozygotes have ataxia and a whole body tremor

ataxia ( J:237902 )

nervous system

decreased Purkinje cell number ( J:237902 )

• histology of two homozygotes at 34 weeks of age found severe Purkinje cell loss

digestive/alimentary system

rectal prolapse ( J:237902 )

• double homozygous mothers on the NOD background often develop rectal prolapse after bearing 1 to 3 litters

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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