Analysis Tools
mortality/aging
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• females exhibit premature loss of fertility
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reproductive system
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• some oocytes within multiple-oocyte follicles at 3 weeks of age lack a zona pollucida and associated granulosa cells
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• stromal cells of 3 month old ovaries are luteinized and look more like the cells of corpus lutea than stroma
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• the majority of ovaries lack normal corpora lutea at 3 months
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• joined follicles are present in 3 week old ovaries, as indicated by the fold of basal lamina and theca cells that partially separates two connected follicles
• by 6 weeks of age, females have more follicular abnormalities and have fewer follicles
• numerous oocytes lacking cumulus cells are seen in follicles at 6 weeks of age
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• some oocytes within multiple-oocyte follicles at 3 weeks of age lack a zona pollucida and associated granulosa cells
• oocytes that lack associated granulosa cells but have a zona pellucida are also seen at 6 weeks of age
• granulosa cells are visible beneath the oocyte zona pellucida in follicles at 3 weeks of age, representing either abnormal follicle development or granulosa cell invasion
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• by 3 months of age, ovaries contain fewer growing follicles, with fewer secondary, preantral, and antral follicles
• however, the total number of follicles is similar to controls, due to increased numbers of primary follicles at the 3a stage
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• increase in numbers of primary follicles at the 3a stage
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• ovaries have decreased follicle development at 3 months of age
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• large antral follicles at 6 weeks have an irregular follicle boundary and contain granulosa cells with an asymmetric distribution
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• fewer antral follicles in ovaries at 3 months of age
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• ovaries of 3 week old mice contain multiple-oocyte follicles
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• at 3 months of age
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• ovaries from 3 month old mice contain abnormal leuteinized-like cells that express 3beta-HSD, the enzyme required to convert pregnenalone to progesterone, indicating that these cells secrete progesterone
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• females exhibit premature loss of fertility
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• at 7 weeks of age, the number of eggs ovulated by females in response to the superovulatory stimulus is less than 10% of controls and by 11 week, the ovulation rate falls to less than 1%
• ovulation of eggs is restricted to the period before 3 months of age
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• females are infertile at 3 months of age
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• females exhibit decreased fertility at 6 weeks and are infertile at 3 months of age
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endocrine/exocrine glands
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• stromal cells of 3 month old ovaries are luteinized and look more like the cells of corpus lutea than stroma
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• the majority of ovaries lack normal corpora lutea at 3 months
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• joined follicles are present in 3 week old ovaries, as indicated by the fold of basal lamina and theca cells that partially separates two connected follicles
• by 6 weeks of age, females have more follicular abnormalities and have fewer follicles
• numerous oocytes lacking cumulus cells are seen in follicles at 6 weeks of age
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• some oocytes within multiple-oocyte follicles at 3 weeks of age lack a zona pollucida and associated granulosa cells
• oocytes that lack associated granulosa cells but have a zona pellucida are also seen at 6 weeks of age
• granulosa cells are visible beneath the oocyte zona pellucida in follicles at 3 weeks of age, representing either abnormal follicle development or granulosa cell invasion
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• by 3 months of age, ovaries contain fewer growing follicles, with fewer secondary, preantral, and antral follicles
• however, the total number of follicles is similar to controls, due to increased numbers of primary follicles at the 3a stage
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• increase in numbers of primary follicles at the 3a stage
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• ovaries have decreased follicle development at 3 months of age
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• large antral follicles at 6 weeks have an irregular follicle boundary and contain granulosa cells with an asymmetric distribution
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• fewer antral follicles in ovaries at 3 months of age
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• ovaries of 3 week old mice contain multiple-oocyte follicles
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• at 3 months of age
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• ovaries from 3 month old mice contain abnormal leuteinized-like cells that express 3beta-HSD, the enzyme required to convert pregnenalone to progesterone, indicating that these cells secrete progesterone
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• females exhibit premature loss of fertility
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homeostasis/metabolism
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• decrease in circulating inhibin A levels
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• testosterone levels are decreased
• however, estradiol, progesterone, and leuteinizing hormone levels are normal
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cellular
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• some oocytes within multiple-oocyte follicles at 3 weeks of age lack a zona pollucida and associated granulosa cells
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