Phenotypes Associated with This Genotype

Genotype
MGI:5816455

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:237232 )

• brown adipose tissue shows hypertrophy, accompanied by presence of large unilocular adipocytes

lipodystrophy ( J:237232 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:237232 )

N • mice shown normal glucose metabolism, with reversal of hyperglycemia to a level that is lower than in wild-type mice and normalized response to glucose challenge

neoplasm

increased liposarcoma incidence ( J:237232 )

• mice develop malignant sarcomas by 3 months of age at various locations of the body, including diaphragm, limb, spine, retroperitoneum, subcutaneous regions, and in the thoracic cavity

• multiple tumors of various sizes are seen in all mice

• tumors show classical biphasic neoplasm with one component of atypical lipomatous tumors and a second component of high-grade sarcoma indicating dedifferentiated liposarcoma

• tumors show heavy infiltration of inflammatory cells which are Cd45+/Ki67-

• treatment with rosigliatazone starting from 3 weeks of age prevents liposarcoma formation at 5 months of age