Phenotypes Associated with This Genotype

Genotype
MGI:5812901

• Allelic Composition: Gt(ROSA)26Sor^tm2(ATF4)Myz/Gt(ROSA)26Sor^tm2(ATF4)Myz; Tg(Myh11-icre/ERT2)1Soff/?
• Genetic Background: either: D2.Cg-Atf4^tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff or B6.Cg-Atf4^tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

calcified aorta ( J:237331 )

♂ • following administration of tamoxifen, mice develop severe medial calcification in aortic sinuses

cellular

increased cardiomyocyte apoptosis ( J:237331 )

♂ • following administration of tamoxifen, there is an increase of apoptotic cells in the aorta

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:237331 )

♂N • following administration of tamoxifen, levels of phosphorus, calcium, cholesterol and triglyceride are similar to controls

muscle

increased cardiomyocyte apoptosis ( J:237331 )

♂ • following administration of tamoxifen, there is an increase of apoptotic cells in the aorta