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Phenotypes Associated with This Genotype
Genotype
MGI:5811882
Allelic
Composition		 Or8a1tm25Mom/Or8a1+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0
Genetic
Background		 involves: 129 * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Tg(tetO-APPSwInd)Dbo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

growth/size/body
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

nervous system
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

respiratory system
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

taste/olfaction
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory