Phenotypes Associated with This Genotype

Genotype
MGI:5811881

• Allelic Composition: Or10a4^tm1Mom/Or10a4⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

growth/size/body

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

nervous system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

abnormal olfactory bulb layer morphology ( J:199798 )

• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb

respiratory system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

taste/olfaction

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons