Phenotypes Associated with This Genotype

Genotype
MGI:5811872

• Allelic Composition: Tg(Gng8-tTA)#Ryba/0; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * C3H/HeJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

growth/size/body

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

nervous system

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

neurodegeneration ( J:176127 )

• neurodegeneration of olfactory sensory neurons, with most lost before 7 days of age

abnormal olfactory sensory neuron physiology ( J:176127 )

• apoptosis in olfactory sensory neurons

• basal stem cell proliferation in the olfactory epithelium is increased

respiratory system

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• apoptosis in olfactory sensory neurons

• basal stem cell proliferation in the olfactory epithelium is increased

taste/olfaction

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• apoptosis in olfactory sensory neurons

• basal stem cell proliferation in the olfactory epithelium is increased