Phenotypes Associated with This Genotype

Genotype
MGI:5811826

• Allelic Composition: Casz1^tm1.1Flc/Casz1^tm1.1Flc; Isl1^tm1(cre)Tmj/Isl1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:221324 )

• embryos are viable and indistinguishable from controls at least until E14.5; however, no mice are recovered postnatally

cardiovascular system

abnormal heart shape ( J:221324 )

• misshapen heart at E14.5

• however, no ventricular septal defects are detected at E14.5

abnormal heart right ventricle morphology ( J:221324 )

• right ventricular wall thickness is significantly reduced at E14.5

• however, left ventricular wall thickness is normal

heart right ventricle hypoplasia ( J:221324 )

• right ventricular hypoplasia at E14.5

cellular

decreased mitotic index ( J:221324 )

• at E12.5, cardiomyocyte mitotic index is significantly reduced in the right ventricles (but not in the left ventricles), as shown by phospho-histone H3 staining