Phenotypes Associated with This Genotype

Genotype
MGI:5811264

• Allelic Composition: Amhr2^tm3(cre)Bhr/Amhr2⁺; Kit^W-v/Kit^W-v; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased ovary tumor incidence ( J:236161 )

• ovarian tumors are seen in 3-12 month old mice

• tumors are bilateral and larger than those of Kit homozygous mutants and are almost entirely positive for cytokeratin 8, suggesting epithelial origin and show active proliferation

increased granulosa cell tumor incidence ( J:236161 )

• about 50% of ovaries contain mixed epithelial and granulosa tumors

increased ovary adenoma incidence ( J:236161 )

• about 50% of ovaries contain mixed epithelial and granulosa tumors

endocrine/exocrine glands

increased ovary tumor incidence ( J:236161 )

• ovarian tumors are seen in 3-12 month old mice

• tumors are bilateral and larger than those of Kit homozygous mutants and are almost entirely positive for cytokeratin 8, suggesting epithelial origin and show active proliferation

increased granulosa cell tumor incidence ( J:236161 )

• about 50% of ovaries contain mixed epithelial and granulosa tumors

increased ovary adenoma incidence ( J:236161 )

• about 50% of ovaries contain mixed epithelial and granulosa tumors

reproductive system

increased ovary tumor incidence ( J:236161 )

• ovarian tumors are seen in 3-12 month old mice

• tumors are bilateral and larger than those of Kit homozygous mutants and are almost entirely positive for cytokeratin 8, suggesting epithelial origin and show active proliferation

increased granulosa cell tumor incidence ( J:236161 )

• about 50% of ovaries contain mixed epithelial and granulosa tumors

increased ovary adenoma incidence ( J:236161 )

• about 50% of ovaries contain mixed epithelial and granulosa tumors