Phenotypes Associated with This Genotype

Genotype
MGI:5811236

• Allelic Composition: Plxnb2^{tm1c(EUCOMM)Wtsi}/Plxnb2^tm1Matl; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL
• Cell Lines: EPD0051_2_D09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:228347 )

N • mice are born at Mendelian ratios and show no defects in neural tube closure or cortical development

abnormal neuronal precursor cell migration ( J:228347 )

• adult mice display migratory defects of neuroblasts in the rostral migratory stream, similar to Plxnb2^tm1Matl homozygotes

abnormal cerebellar lobule formation ( J:228347 )

• adult mice display underdevelopment of the rostral lobules with fusion of lobules 1-3, similar to Plxnb2^tm1Matl homozygotes

abnormal olfactory bulb development ( J:228347 )

abnormal rostral migratory stream morphology ( J:228347 )

• migrating cells in the rostral migratory stream (RMS) persist in chain formation after exiting the RMS, similar to Plxnb2^tm1Matl homozygotes

ectopic cerebellar granule cells ( J:228347 )

• adult mice display ectopias of granule cells in the molecular layer of caudal lobules, similar to Plxnb2^tm1Matl homozygotes

cellular

abnormal neuronal precursor cell migration ( J:228347 )

• adult mice display migratory defects of neuroblasts in the rostral migratory stream, similar to Plxnb2^tm1Matl homozygotes