Phenotypes Associated with This Genotype

Genotype
MGI:5811097

• Allelic Composition: Tg(Cd4-NPM/ALK)N1Ingh/0; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: involves: C57BL/6 * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:235890 )

• means survival of 181 days

neoplasm

increased gastrointestinal stromal tumor incidence ( J:235890 )

• mice exposed to MHV-OVA develop heptoacellular carcinomas and sarcomas

increased T cell derived lymphoma incidence ( J:235890 )

• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation

• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma

• tumors do not show endogenous TCRbeta rearrangements

• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development

increased hepatocellular carcinoma incidence ( J:235890 )

• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development and develop hepatocellular carcinomas and sarcomas

increased sarcoma incidence ( J:235890 )

• mice exposed to MHV-OVA develop heptoacellular carcinomas and sarcomas

digestive/alimentary system

increased gastrointestinal stromal tumor incidence ( J:235890 )

• mice exposed to MHV-OVA develop heptoacellular carcinomas and sarcomas

endocrine/exocrine glands

abnormal thymus morphology ( J:235890 )

• total thymic cellularity is increased

• however, mice have normal T-cell development profiles

increased T cell derived lymphoma incidence ( J:235890 )

• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation

• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma

• tumors do not show endogenous TCRbeta rearrangements

• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development

hematopoietic system

abnormal thymus morphology ( J:235890 )

• total thymic cellularity is increased

• however, mice have normal T-cell development profiles

increased T cell derived lymphoma incidence ( J:235890 )

• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation

• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma

• tumors do not show endogenous TCRbeta rearrangements

• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development

abnormal double-negative T cell morphology ( J:235890 )

• increase in cellular proliferation of the DN3 population

immune system

abnormal thymus morphology ( J:235890 )

• total thymic cellularity is increased

• however, mice have normal T-cell development profiles

increased T cell derived lymphoma incidence ( J:235890 )

• mice develop ALK+ lymphomas, with a peripheral rather than thymic presentation

• tumors show cells with eosinophilic cytoplasm and reniform nuclei, resembling the classic hallmark cells of human anaplastic large cell lymphoma

• tumors do not show endogenous TCRbeta rearrangements

• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development

abnormal double-negative T cell morphology ( J:235890 )

• increase in cellular proliferation of the DN3 population

liver/biliary system

increased hepatocellular carcinoma incidence ( J:235890 )

• mice exposed to MHV-OVA show abrogated anaplastic large cell lymphoma development and develop hepatocellular carcinomas and sarcomas