Phenotypes Associated with This Genotype

Genotype
MGI:5810678

• Allelic Composition: Gli3^tm3.1Blnw/Gli3⁺; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:199480 )

• ~50% of mice display hindlimb autopods with fused digits, while the rest have normal hindlimb autopods

decreased autopod size ( J:199480 )

• E16.5 forelimb autopods are much smaller than those in control mice

brachydactyly ( J:199480 )

• forelimb digits are shorter

oligodactyly ( J:199480 )

• at E16.5, forelimb digit number varies from 3 to 5, with some digits fused (oligosyndactyly)

• at E16.5, two of 5 mice show normal hindlimb autopods, while the rest show 3 to 5 digits, some of which are fused or partial

syndactyly ( J:199480 )

• forelimb digits are fused and shorter, making it difficult to determine digit number

• ~50% of mice display hindlimb autopods with fused digits

short humerus ( J:199480 )

• at E16.5, the humerus is slightly shorter than that in wild-type controls

abnormal forelimb zeugopod morphology ( J:199480 )

• at E16.5, the forelimb zeugopod elements, radius and ulna, are bent and much shorter than those in control mice

bowed radius ( J:199480 )

• at E16.5

short radius ( J:199480 )

• at E16.5, the radius is much shorter than that in wild-type controls

bowed ulna ( J:199480 )

• at E16.5

short ulna ( J:199480 )

• at E16.5, the ulna is much shorter than that in wild-type controls

short forelimb ( J:199480 )

• adult and E16.5 forelimbs are markedly shorter with consistently smaller autopods than those in control mice

abnormal hindlimb morphology ( J:199480 )

• ~50% of adult and E16.5 mice display hindlimb autopods with fused digits

• however, hindlimb length is normal

short femur ( J:199480 )

• at E16.5, the femur is slightly shorter than that in wild-type controls

• however, patterning appears normal

short fibula ( J:199480 )

• at E16.5, the fibula is slightly shorter than that in wild-type controls

• however, patterning appears normal

short tibia ( J:199480 )

• at E16.5, the tibia is slightly shorter than that in wild-type controls

• however, patterning appears normal

skeleton

short humerus ( J:199480 )

• at E16.5, the humerus is slightly shorter than that in wild-type controls

bowed radius ( J:199480 )

• at E16.5

short radius ( J:199480 )

• at E16.5, the radius is much shorter than that in wild-type controls

bowed ulna ( J:199480 )

• at E16.5

short ulna ( J:199480 )

• at E16.5, the ulna is much shorter than that in wild-type controls

short femur ( J:199480 )

• at E16.5, the femur is slightly shorter than that in wild-type controls

• however, patterning appears normal

short fibula ( J:199480 )

• at E16.5, the fibula is slightly shorter than that in wild-type controls

• however, patterning appears normal

short tibia ( J:199480 )

• at E16.5, the tibia is slightly shorter than that in wild-type controls

• however, patterning appears normal

short scapula ( J:199480 )

• at E16.5, the distal scapula is slightly shorter than that in wild-type controls

failure of endochondral bone ossification ( J:199480 )

• at E16.5, forelimb autopods often lack ossification