Phenotypes Associated with This Genotype

Genotype
MGI:5807362

• Allelic Composition: Slc6a14^tm1Gana/Slc6a14^tm1Gana; Tg(MMTVneu)202Mul/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:226105 )

♀ • at 10 months of age, the % of mice with palpable mammary tumors is significantly lower than that in age-matched mice carrying the transgene on a wild-type background

decreased tumor growth/size ( J:226105 )

♀ • at 15 months of age, mice show a significant decrease in mammary tumor volume relative to age-matched mice carrying the transgene on a wild-type background

increased tumor latency ( J:226105 )

♀ • mice develop the first palpable mammary tumor at ~500 days, i.e. significantly later than mice carrying the transgene on a wild-type background

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:226105 )

♀ • at 10 months of age, the % of mice with palpable mammary tumors is significantly lower than that in age-matched mice carrying the transgene on a wild-type background

integument

decreased mammary gland tumor incidence ( J:226105 )

♀ • at 10 months of age, the % of mice with palpable mammary tumors is significantly lower than that in age-matched mice carrying the transgene on a wild-type background