Slc6a14^tm1Gana
Targeted Allele Detail

Summary

• Symbol: Slc6a14^tm1Gana
• Name: solute carrier family 6 (neurotransmitter transporter), member 14; targeted mutation 1, Vadivel Ganapathy
• MGI ID: MGI:5788552
• Synonyms: Slc6a14^-
• Gene: Slc6a14 Location: ChrX:21581139-21608597 bp, + strand Genetic Position: ChrX, 16.78 cM, cytoband A2
• Alliance: Slc6a14^tm1Gana page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226105
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele contains a 2.6 kb deletion of a region containing exons 1 and 2 and ~1 kb of the sequence upstream of exon 1. mRNA expressed from this allele was not detected in colon and lung from both hemizygous males and homozygous females in contrast to wild-type controls. No encoded protein was found in colon and lung from homozygous females as evident from immunofluorescence studies. The mRNA was not detectable in normal wild-type mouse mammary gland. In colon and lung of homozygous females, there were no major compensatory changes in the expression of any of the 12 amino acid transporter mRNAs examined. (J:226105)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Slc6a14^tm1Gana

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a14 Mutation: 11 strains or lines available

References

• Original: J:226105 Babu E, et al., Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. Biochem J. 2015 Jul 1;469(1):17-23
• All: 5 reference(s)