Phenotypes Associated with This Genotype

Genotype
MGI:5807149

• Allelic Composition: Cdc42^tm1Brak/Cdc42^tm1Brak; Tg(Pax8-rtTA2S*M2)1Koes/0; Tg(tetO-cre)LC1Bjd/0
• Genetic Background: involves: BALB/c * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to kidney reperfusion injury ( J:221423 )

• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function

renal/urinary system

increased susceptibility to kidney reperfusion injury ( J:221423 )

• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function

abnormal renal tubule epithelium morphology ( J:221423 )

• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function

• dividing cells of doxycycline-treated mice during kidney repair show a high shift toward mitotic spindle angles perpendicular to the epithelial plane

• however, doxycline-treated mice exhibit normal kidney histology and function under basal conditions