Phenotypes Associated with This Genotype

Genotype
MGI:5803705

• Allelic Composition: Pmp2^{tm1.1(KOMP)Vlcg}/Pmp2^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased nerve conduction velocity ( J:211344 )

• electrophysiological analysis of the sciatic nerve revealed a mild reduction in motor nerve conduction velocity (MNCV) at P28 and a significant reduction of MNCV at P56 relative to wild-type controls; however, normal MNCV values are reached at P224

• despite temporary reduction in MNCV, PNS structure is normal as shown by normal periodicity of peripheral myelin at P10, normal distribution of Na_v- and K_v1.2-channels in teased sciatic nerve fibers at P56, as well as normal myelin thickness, axonal distribution and axonal numbers in the sciatic nerve at P10, P56, and P224

homeostasis/metabolism

abnormal lipid homeostasis ( J:211344 )

• mice exhibit changes in the lipid composition of purified PNS myelin isolated from sciatic nerves at P10; however, differences detected at P10 are reduced upon maturation of the PNS, with normal myelin lipidomes seen at P56

behavior/neurological

behavior/neurological phenotype ( J:211344 )

N • adult mice do not exhibit hind limb clasping when lifted up by their tail