Phenotypes Associated with This Genotype

Genotype
MGI:5800496

• Allelic Composition: Ncstn^tm1.1Sud/Ncstn^tm1.1Sud; Olig1^tm1(cre)Rth/Olig1⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased exploration in new environment ( J:234705 )

• mice exhibit increased exploratory behavior in both the open field and elevated plus maze

increased grooming behavior ( J:234705 )

• compulsive grooming in symptomatic mice

• presymptomatic mice show a trend towards excessive grooming

hyperactivity ( J:234705 )

• mice are hyperactive in both the open field and elevated plus maze

• treatment with an acute intraperitoneal injection of a low dose of haloperidol reverses the hyperactivity but does not alter the thigmotaxis in the open field maze

increased stereotypic behavior ( J:234705 )

• mice exhibit trichotillomania

integument

abnormal coat appearance ( J:234705 )

• aged mice exhibit extensive bald patches localized to the nape of the neck and upper back

skin lesions ( J:234705 )

• bald patches progress to full lesions with 100% penetrance by 9 months of age

• lesions are self-inflicted and not caused by social grooming

• lesions are not responsive to topical antibiotic, anti-inflammatory, or antihistamine treatment and mice do not exhibit a difference in response to histamine injection compared to controls

nervous system

decreased myelin sheath thickness ( J:234705 )

• thinner myelin sheaths in the optic nerve, indicating hypomyelination in the optic nerve

• however, myelination in the spinal cord and sciatic nerve is normal

dysmyelination ( J:234705 )

• hypomyelination in the optic nerve

decreased prepulse inhibition ( J:234705 )

• mice are less sensitive to the prepulse and thus show reduced inhibition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:234705