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Phenotypes Associated with This Genotype
Genotype
MGI:5800452
Allelic
Composition		 P2ry2tm1c(EUCOMM)Hmgu/P2ry2tm1c(EUCOMM)Hmgu
Tg(Tek-icre/ERT2)1Soff/0
Genetic
Background		 B6N.Cg-P2ry2tm1c(EUCOMM)Hmgu Tg(Tek-icre/ERT2)1Soff
Cell Lines HEPD0557_7_B07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry2tm1c(EUCOMM)Hmgu mutation (0 available); any P2ry2 mutation (16 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal

muscle
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory