Phenotypes Associated with This Genotype

Genotype
MGI:5797327

• Allelic Composition: Aak1^{tm1b(EUCOMM)Hmgu}/Aak1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Aak1^{tm1b(EUCOMM)Hmgu}/Orl
• Cell Lines: HEPD0691_2_C07

Data Sources

IMPC Data for Aak1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:211773 )

IMPC - ICS

decreased startle reflex ( J:211773 )

♂

IMPC - ICS

decreased grip strength ( J:211773 )

IMPC - ICS

hyperactivity ( J:211773 )

IMPC - ICS

increased vertical activity ( J:211773 )

IMPC - ICS

cardiovascular system

abnormal heart left ventricle morphology ( J:211773 )

IMPC - ICS

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - ICS

homeostasis/metabolism

decreased circulating cholesterol level ( J:211773 )

IMPC - ICS

increased circulating alanine transaminase level ( J:211773 )

♀

IMPC - ICS

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - ICS

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - ICS

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - ICS

decreased circulating total protein level ( J:211773 )

IMPC - ICS

impaired glucose tolerance ( J:211773 )

♂

IMPC - ICS

limbs/digits/tail

short tibia ( J:211773 )

IMPC - ICS

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - ICS

nervous system

increased prepulse inhibition ( J:211773 )

♂

IMPC - ICS

skeleton

short tibia ( J:211773 )

IMPC - ICS

abnormal bone structure ( J:211773 )

♀

IMPC - ICS

vision/eye

abnormal retina outer nuclear layer morphology ( J:211773 )

IMPC - ICS