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Phenotypes Associated with This Genotype
Genotype
MGI:5796164
Allelic
Composition		 Rb1tm2Brn/Rb1+
Trp53tm1Brn/Trp53tm1Brn
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129 * 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:234128 )
• mice survive up to 55.4 weeks of age

neoplasm
increased osteosarcoma incidence ( J:234128 )
• mice develop osteosarcoma by 35 weeks of age
• tumors are marked by low TNFSF11 (RANKL)/high TNFRSF11A (RANK) levels

skeleton
increased osteosarcoma incidence ( J:234128 )
• mice develop osteosarcoma by 35 weeks of age
• tumors are marked by low TNFSF11 (RANKL)/high TNFRSF11A (RANK) levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory