Analysis Tools
mortality/aging
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• mice die suddenly between 14 and 40 weeks of age
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digestive/alimentary system
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• microabscesses in the crypts
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• decrease in the number of mucus-secreting cells
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• alterations and lesions of the glandular epithelium
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• 3 of 7 and 4 of 5 mice show indications of ulcerative colitis at 8 weeks and 16 weeks of age, respectively
• all mice exhibit severe colitis aggravated by fibrosis and mucosal pseudopolyposis at 36 weeks of age
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endocrine/exocrine glands
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• microabscesses in the crypts
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• cellularity of thymus is slightly reduced in 8 week old mutants
• however, no alterations in the cortex and medulla are seen
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• weight of thymus is slightly reduced in 8 week old mutants
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hematopoietic system
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• cellularity of thymus is slightly reduced in 8 week old mutants
• however, no alterations in the cortex and medulla are seen
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• weight of thymus is slightly reduced in 8 week old mutants
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• hemopoiesis is mainly directed to the production of granulocytes
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• bone marrow erythropoiesis is deficient
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• bone marrow lymphopoiesis is deficient
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• bone marrow shows a predominance of segmented cells and a decrease in the proportion of red cells and lymphocytes
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• granulocytosis is seen in 8 week old mutants which progresses with age
• bone marrow shows an increase of CD11b+ granulocyte lineage at 16 weeks
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• severe lymphopenia is seen in 8 week old mutants which progresses with age
• however, no changes in platelet number or volume are seen
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• bone marrow shows a reduction of B cells at 16 weeks of age
• progressive age-related reduction in the percentage of B cells in the lymph nodes and Peyers patches
• both at 16 and 28 weeks of age, B cells in the periarteriolar sheath of the spleen are reduced
• at 28 weeks of age, B cells are decreased to 25% of the normal number in the spleen
• peripheral blood shows a reduction of B220+ cells
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• slight reduction in the number of B220+ cells in the spleen of 8 week old mice, with a severe reduction in the area containing follicular B cells (B220+) from 16 weeks of age
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• the marginal zone compartment is smaller in the spleen of 16 week old mice
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• bone marrow shows an increase of monocyte lineages at 16 weeks
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• more than 50% reduction of CD4+, and CD8+ cells in the spleen
• increase in the percentage of CD4+ and CD8+ cells in the lymph nodes and Peyers patches
• peripheral blood shows a reduction of CD4+ and CD8+ cells
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• at 36 weeks of age, spleen is almost entirely hematopoietic and mainly composed of erythroid tissue
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• spleens of 16 week old mice are enlarged and are greatly swollen at 36 weeks of age
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• increase of red pulp in the spleen of 16 week old mice
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• decrease of white pulp in the spleen of 16 week old mice, with white pulp greatly diminished at 36 weeks of age
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• IgA deposits within the mesangium
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immune system
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• 3 of 7 and 4 of 5 mice show indications of ulcerative colitis at 8 weeks and 16 weeks of age, respectively
• all mice exhibit severe colitis aggravated by fibrosis and mucosal pseudopolyposis at 36 weeks of age
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• cellularity of thymus is slightly reduced in 8 week old mutants
• however, no alterations in the cortex and medulla are seen
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• weight of thymus is slightly reduced in 8 week old mutants
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• bone marrow lymphopoiesis is deficient
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• granulocytosis is seen in 8 week old mutants which progresses with age
• bone marrow shows an increase of CD11b+ granulocyte lineage at 16 weeks
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• severe lymphopenia is seen in 8 week old mutants which progresses with age
• however, no changes in platelet number or volume are seen
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• bone marrow shows a reduction of B cells at 16 weeks of age
• progressive age-related reduction in the percentage of B cells in the lymph nodes and Peyers patches
• both at 16 and 28 weeks of age, B cells in the periarteriolar sheath of the spleen are reduced
• at 28 weeks of age, B cells are decreased to 25% of the normal number in the spleen
• peripheral blood shows a reduction of B220+ cells
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• slight reduction in the number of B220+ cells in the spleen of 8 week old mice, with a severe reduction in the area containing follicular B cells (B220+) from 16 weeks of age
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• the marginal zone compartment is smaller in the spleen of 16 week old mice
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• bone marrow shows an increase of monocyte lineages at 16 weeks
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• more than 50% reduction of CD4+, and CD8+ cells in the spleen
• increase in the percentage of CD4+ and CD8+ cells in the lymph nodes and Peyers patches
• peripheral blood shows a reduction of CD4+ and CD8+ cells
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• at 36 weeks of age, spleen is almost entirely hematopoietic and mainly composed of erythroid tissue
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• spleens of 16 week old mice are enlarged and are greatly swollen at 36 weeks of age
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• increase of red pulp in the spleen of 16 week old mice
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• decrease of white pulp in the spleen of 16 week old mice, with white pulp greatly diminished at 36 weeks of age
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• IgA deposits within the mesangium
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• increase in the percentage of CD4+ and CD8+ cells in the Peyers patches
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• at 16 weeks of age, the B-lymphoid cortical zone of lymph nodes is thinner
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• serum contains antibodies specific for nuclear and/or cytoplasmic antigens
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• 1/3 of mice show inflammation of the hip and knee joints at 36 weeks of age
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• mesangial proliferative glomerulonephritis with focal and segmental alternations becomes evident at 8 weeks of age
• glomerular lesions consist of increased mesangial matrix and mesangial hypercellularity that are mild at 8 weeks, moderate and severe at 16 weeks
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• all mice exhibit interstitial inflammation in the lungs at 16 and 36 weeks of age, confined to the walls of alveoli
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• signs of hypersensitive pneumonitis, usually centered on bronchioles, is seen in 5/11 mice at 16-36 weeks of age
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renal/urinary system
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• mesangial proliferative glomerulonephritis with focal and segmental alternations becomes evident at 8 weeks of age
• glomerular lesions consist of increased mesangial matrix and mesangial hypercellularity that are mild at 8 weeks, moderate and severe at 16 weeks
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• diffuse, arborized granular deposits within the mesangium are composed of IgA, in combination with small amounts of IgG
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• occasional segmental sclerosis and hyalinosis
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respiratory system
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• all mice exhibit interstitial inflammation in the lungs at 16 and 36 weeks of age, confined to the walls of alveoli
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• signs of hypersensitive pneumonitis, usually centered on bronchioles, is seen in 5/11 mice at 16-36 weeks of age
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skeleton
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• 1/3 of mice show inflammation of the hip and knee joints at 36 weeks of age
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growth/size/body
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• spleens of 16 week old mice are enlarged and are greatly swollen at 36 weeks of age
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