Phenotypes Associated with This Genotype

Genotype
MGI:5795709

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Ctnnbl1^tm1.1Crad/Ctnnbl1^tm1.1Crad
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:232010 )

N • mice exhibit normal splenic B cells numbers and early stages of B cell differentiation

abnormal B cell proliferation ( J:232010 )

• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells

decreased B cell proliferation ( J:232010 )

• in response to LPS or anti-CD40 stimulation

abnormal class switch recombination ( J:232010 )

• reduced immunoglobin class switching in splenic B cells

hematopoietic system

abnormal B cell proliferation ( J:232010 )

• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells

decreased B cell proliferation ( J:232010 )

• in response to LPS or anti-CD40 stimulation

abnormal class switch recombination ( J:232010 )

• reduced immunoglobin class switching in splenic B cells

cellular

abnormal B cell proliferation ( J:232010 )

• delayed entry into S phase on activation of resting, affecting follicular more than marginal zone B cells

decreased B cell proliferation ( J:232010 )

• in response to LPS or anti-CD40 stimulation