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Phenotypes Associated with This Genotype
Genotype
MGI:5792842
Allelic
Composition		 Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber morphology ( J:233994 )
• 2 weeks after tamoxifen-treatment, the total number of cardiomyocytes and percentage of mononucleated cardiomyocytes compared with control mice
decreased myocardial fiber size ( J:233994 )
• 2 weeks after tamoxifen-treatment
increased myocardial fiber number ( J:233994 )
• 2 weeks after tamoxifen-treatment
increased heart weight ( J:233994 )
• increased heart weight to tibia length ratio 2 weeks after tamoxifen treatment
abnormal myocardial fiber physiology ( J:233994 )
• cardiomyocytes reenter the cell cycle 8 days after tamoxifen treatment
• increased cardiomyocytes proliferation in tamoxifen treated mice following induction of myocardial infarction
abnormal response to cardiac infarction ( J:233994 )
• following induced myocardial infarction, tamoxifen-treated mice exhibit reduced fibrotic scarring with increased myocardial tissue compared with control mice
• however, mice exhibit ventricular dilation and reduced fractional shortening and ejection fraction 3 weeks after injury

cellular
decreased cardiomyocyte apoptosis ( J:233994 )
• 8 days after tamoxifen treatment

homeostasis/metabolism
abnormal response to cardiac infarction ( J:233994 )
• following induced myocardial infarction, tamoxifen-treated mice exhibit reduced fibrotic scarring with increased myocardial tissue compared with control mice
• however, mice exhibit ventricular dilation and reduced fractional shortening and ejection fraction 3 weeks after injury

muscle
abnormal myocardial fiber morphology ( J:233994 )
• 2 weeks after tamoxifen-treatment, the total number of cardiomyocytes and percentage of mononucleated cardiomyocytes compared with control mice
decreased myocardial fiber size ( J:233994 )
• 2 weeks after tamoxifen-treatment
increased myocardial fiber number ( J:233994 )
• 2 weeks after tamoxifen-treatment
decreased cardiomyocyte apoptosis ( J:233994 )
• 8 days after tamoxifen treatment

growth/size/body
increased heart weight ( J:233994 )
• increased heart weight to tibia length ratio 2 weeks after tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory