Gt(ROSA)26Sor^{tm1.1(CAG-Mirc20)Eem}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-Mirc20)Eem}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Edward E Morrisey
• MGI ID: MGI:5792834
• Synonyms: R26R-miR302-367^Tg
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-Mirc20)Eem} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233994
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(CAG-Mirc20)Eem} expresses 4 genes
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir302a (MGI:3619325)
  mouse	Mir302b (MGI:3619326)
  mouse	Mir302d (MGI:3619328)
  mouse	Mirc20 (MGI:5313577)

• Mutation details: The targeting construct inserted into the locus a CAG promoter, floxed neomycin resistance cassette, and the Mirc20 microRNA cluster and FRT-flanked neomycin resistance cassette flanked by the 5' and 3' H sequence. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:233994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:233994 Tian Y, et al., A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015 Mar 18;7(279):279ra38
• All: 2 reference(s)