Phenotypes Associated with This Genotype

Genotype
MGI:5792820

• Allelic Composition: Ccno^{tm1b(EUCOMM)Wtsi}/Ccno^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:220709 )

nervous system

hydrocephaly ( J:220709 )

• prominent in 20 of 35 mice

enlarged brain ventricles ( J:220709 )

• massively enlarged in some mice

thin cerebral cortex ( J:220709 )

respiratory system

nasal obstruction ( J:220709 )

• mucosal congestion in all mice

abnormal tracheal ciliated epithelium morphology ( J:220709 )

• complete absence cilia is observed at E17

• adult mice exhibit reduced cilia number, reduced grouping and undecorated margins compared with wild-type mice

• epithelial cells exhibit multiple mislocalized and misshaped basal bodies that fail to correctly dock to the apical plasma membrane and to extend ciliary axonemes compared with wild-type cells

• cells exhibit abnormal deuterosome and centriole formation compared with wild-type cells

• however, single cilia exhibit normal gross morphology

growth/size/body

abnormal head morphology ( J:220709 )

• due to hydrocephaly

nasal obstruction ( J:220709 )

• mucosal congestion in all mice

postnatal growth retardation ( J:220709 )

craniofacial

nasal obstruction ( J:220709 )

• mucosal congestion in all mice

immune system

immune system phenotype ( J:220709 )

N • mice do not exhibit any signs of inflammation or mucus congestion in lung tissues