Phenotypes Associated with This Genotype

Genotype
MGI:5792803

• Allelic Composition: Sox17^tm2Sjm/Sox17^tm2Sjm; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal artery morphology ( J:234137 )

• under prolonged angiotensin II (AT II) infusion, tamoxifen treated mice show luminal dilation, wall thinning, and decreased vascular smooth muscle layers at multiple vascular locations around the distal intracerebral bifurcation of intracerebral arteries

• under AT II infusion, endothelial junctions of intracerebral arteries from tamoxifen treated mice are severely disrupted

• under AT II infusion, intracerebral arteries from tamoxifen treated mice show infrequent focal endothelial denudation

abnormal abdominal aorta morphology ( J:234137 )

• under moderate AT II infusion, abdominal aorta of tamoxifen treated mice shows a modest decrease in wall thickness but does not show luminal dilation

abnormal thoracic aorta morphology ( J:234137 )

• under moderate AT II infusion, thoracic aorta of tamoxifen treated mice shows a modest decrease in wall thickness but does not show luminal dilation

aortic dissection ( J:234137 )

• tamoxifen treated mice under AT II infusion occasionally exhibit arterial dissection on the walls of intracranial arteries

abnormal blood vessel endothelium morphology ( J:234137 )

• under AT II infusion, endothelial layers in vessels of tamoxifen treated mice exhibit an abnormal lateral morphology with an irregular and flattened shape

abnormal vascular smooth muscle morphology ( J:234137 )

• arteries from tamoxifen treated mice have less coverage by vascular smooth muscle cells

aneurysm ( J:234137 )

• about 25% of tamoxifen treated mice show abnormally enlarged structure with tortuosity resembling fusiform dilation or a balloon-like structure indicative of saccular aneurysm

• 60% of tamoxifen treated mice subjected to a moderate hypertensive condition by infusion with a low dose of angiotensin II (AT II) exhibit features of intracranial aneurysm, showing vascular enlargement of intracerebral arteries, luminal dilation, and wall thinning

hemorrhage ( J:234137 )

• tamoxifen treated mice under AT II infusion frequently exhibit hemorrhage in cerebrospinal fluid, in the intracranial region, and in the intramural region

• hemorrhage is infrequently seen in mutants under steady state conditions

increased vascular permeability ( J:234137 )

• under AT II infusion, intracerebral arteries from tamoxifen treated mice show increased stress-induced leakage of intravenously infused Evans blue dye

cellular

decreased endothelial cell proliferation ( J:234137 )

• AT II-induced endothelial proliferation is suppressed in the vessels of tamoxifen treated mice

muscle

abnormal vascular smooth muscle morphology ( J:234137 )

• arteries from tamoxifen treated mice have less coverage by vascular smooth muscle cells