Phenotypes Associated with This Genotype

Genotype
MGI:5792566

• Allelic Composition: Fermt2^tm1.1Gxo/Fermt2^tm1.1Gxo; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: B6.Cg-Fermt2^tm1.1Gxo Tg(Col2a1-cre)1Bhr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:224370 )

• mice die within 1 month of birth because of respiratory distress

growth/size/body

decreased body size ( J:224370 )

• severe dwarfism at P20

postnatal growth retardation ( J:224370 )

• all mice develop rapid growth retardation after birth

respiratory system

respiratory distress ( J:224370 )

• respiratory distress probably associated with compression of cervical and thoracic vertebrae as a result of kyphosis

limbs/digits/tail

decreased femur compact bone thickness ( J:224370 )

• significant reduction in femur cortical bone thickness at P30

short limbs ( J:224370 )

• P0 forelimbs and hindlimbs are shorter than normal

skeleton

skeleton phenotype ( J:224370 )

N • mice do not exhibit any marked abnormalities in the skull vault and clavicle, suggesting normal intramembraneous ossification

abnormal skeleton morphology ( J:224370 )

• reduced skeleton size at P0 and P20

decreased femur compact bone thickness ( J:224370 )

• significant reduction in femur cortical bone thickness at P30

abnormal long bone epiphyseal plate morphology ( J:224370 )

• at P0, representative images of proliferative and hypertrophic zone chondrocytes show disrupted column formation in humeral sections

decreased length of long bones ( J:224370 )

• significant reduction in the length of all long bones (femur, tibia, humerus, radius and ulna) and their respective bony portions at P0

small thoracic cage ( J:224370 )

• P0 ribcage is smaller than normal

kyphosis ( J:224370 )

• ~80% of mice develop progressive kyphosis

• severe kyphosis at P20

vertebral compression ( J:224370 )

• compression of cervical and thoracic vertebrae resulting from kyphosis

small vertebrae ( J:224370 )

• vertebrae are shorter than normal

decreased bone mineral density ( J:224370 )

decreased trabecular bone volume ( J:224370 )

• dramatic reduction in femur trabecular bone volume/tissue volume (BV/TV) at P30

delayed endochondral bone ossification ( J:224370 )

• Alcian blue stain of P17 and P30 tibial sections indicates delayed formation of the secondary ossification center and reduced subchondral bone