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Phenotypes Associated with This Genotype
Genotype
MGI:5792144
Allelic
Composition
Hdac6tm1Anfi/Hdac6tm1Anfi
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1Anfi mutation (0 available); any Hdac6 mutation (14 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes

nervous system
• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes

behavior/neurological
N
• mice show rescue of the mild hyperactivity seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
• mice show complete rescue of the impaired freezing behavior seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes, restoring associative memory
• mice show improved spatial memory function compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory