homeostasis/metabolism
• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
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nervous system
• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
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behavior/neurological
N |
• mice show rescue of the mild hyperactivity seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
• mice show complete rescue of the impaired freezing behavior seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes, restoring associative memory
• mice show improved spatial memory function compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
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