Phenotypes Associated with This Genotype

Genotype
MGI:5792055

• Allelic Composition: Cacna1a^tg/Cacna1a^tm2.1Maag; Tg(Pcp2-cre)2Mpin/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

dystonia ( J:233263 )

• mice exhibit dystonia that is more severe than in single Cacna1a^tg homozygotes

• more than 95% of abnormal movements are either tonic or clonic

• mice show a small (5%) but significant shift towards increased head/neck postures than in single Cacna1a^tg homozygotes

muscle

dystonia ( J:233263 )

• mice exhibit dystonia that is more severe than in single Cacna1a^tg homozygotes

• more than 95% of abnormal movements are either tonic or clonic

• mice show a small (5%) but significant shift towards increased head/neck postures than in single Cacna1a^tg homozygotes