Phenotypes Associated with This Genotype

Genotype
MGI:5790984

• Allelic Composition: Nsun2^{tm1a(EUCOMM)Wtsi}/Nsun2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0105_2_F10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oligozoospermia ( J:213427 )

• epididymal hypospermia

liver/biliary system

abnormal liver physiology ( J:213427 )

• decreased or absent hepatic lipidosis

adipose tissue

decreased total body fat amount ( J:213427 )

decreased percent body fat/body weight ( J:213427 )

endocrine/exocrine glands

testis degeneration ( J:213427 )

behavior/neurological

decreased grip strength ( J:213427 )

hyperactivity ( J:213427 )

craniofacial

abnormal cranium morphology ( J:213427 )

abnormal tooth morphology ( J:213427 )

abnormal snout morphology ( J:213427 )

growth/size/body

abnormal tooth morphology ( J:213427 )

abnormal snout morphology ( J:213427 )

decreased lean body mass ( J:213427 )

decreased body weight ( J:213427 )

decreased body length ( J:213427 )

hematopoietic system

increased erythrocyte cell number ( J:213427 )

decreased mean corpuscular hemoglobin ( J:213427 )

decreased mean corpuscular volume ( J:213427 )

homeostasis/metabolism

decreased circulating glucose level ( J:213427 )

decreased circulating cholesterol level ( J:213427 )

decreased circulating HDL cholesterol level ( J:213427 )

decreased circulating LDL cholesterol level ( J:213427 )

decreased circulating free fatty acids level ( J:213427 )

decreased circulating glycerol level ( J:213427 )

decreased circulating amylase level ( J:213427 )

decreased energy expenditure ( J:213427 )

increased energy expenditure ( J:213427 )

increased carbon dioxide production ( J:213427 )

increased oxygen consumption ( J:213427 )

improved glucose tolerance ( J:213427 )

integument

abnormal hair cycle anagen phase ( J:213427 )

abnormal hair shedding ( J:213427 )

limbs/digits/tail

abnormal humerus morphology ( J:213427 )

abnormal deltoid tuberosity morphology ( J:213427 )

mortality/aging

lethality, incomplete penetrance ( J:213427 )

reproductive system

oligozoospermia ( J:213427 )

• epididymal hypospermia

testis degeneration ( J:213427 )

abnormal fertility/fecundity ( J:213427 )

skeleton

abnormal cranium morphology ( J:213427 )

abnormal tooth morphology ( J:213427 )

abnormal humerus morphology ( J:213427 )

abnormal deltoid tuberosity morphology ( J:213427 )

decreased length of long bones ( J:213427 )

abnormal spine curvature ( J:213427 )

kyphosis ( J:213427 )

lordosis ( J:213427 )

decreased bone mineral content ( J:213427 )

decreased bone mineral density ( J:213427 )

abnormal joint morphology ( J:213427 )

vision/eye

abnormal cornea morphology ( J:213427 )

abnormal lens morphology ( J:213427 )

cataract ( J:213427 )