Phenotypes Associated with This Genotype

Genotype
MGI:5790811

• Allelic Composition: Ccdc80^tm1Ppal/Ccdc80^tm1Ppal
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased ovarian carcinoma incidence ( J:217742 )

• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis

increased thyroid adenoma incidence ( J:217742 )

• 6 of 20 (30%) of homozygotes developed thyroid adenomas

• thyroid adenomas and ovarian carcinomas were never present in the same mouse

increased metastatic potential ( J:217742 )

• 1 of 4 ovarian carcinomas showed the presence of liver metastasis

cellular

decreased fibroblast apoptosis ( J:217742 )

• after 72 hrs of serum starvation, the % of apoptotic MEFs (sub-G1 cell population) was lower than that in wild-type MEFs

• after treatment with 500 nM doxorubicin for 16 hrs, the % of TUNEL-positive MEFs was significantly lower than that in wild-type MEFs

increased fibroblast proliferation ( J:217742 )

• mouse embryonic fibroblasts (MEFs) derived from E12.5 embryos showed a significantly higher proliferation rate than wild-type MEFs

endocrine/exocrine glands

increased ovarian carcinoma incidence ( J:217742 )

• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis

increased thyroid adenoma incidence ( J:217742 )

• 6 of 20 (30%) of homozygotes developed thyroid adenomas

• thyroid adenomas and ovarian carcinomas were never present in the same mouse

reproductive system

increased ovarian carcinoma incidence ( J:217742 )

• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis