Phenotypes Associated with This Genotype

Genotype
MGI:5790397

• Allelic Composition: Arhgap35^m1Bchd/Arhgap35^tm1Jset
• Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hypoplastic and glomerulocystic kidneys in Arhgap35^tm1Jset/Arhgap35^m1Bchd mutants

mortality/aging

perinatal lethality, complete penetrance ( J:232342 )

• early perinatal lethality

renal/urinary system

abnormal kidney morphology ( J:232342 )

• 100% of E17.5 embryos display hypodysplastic kidneys

renal glomerulus cyst ( J:232342 )

• cystic glomeruli at E17.5

renal hypoplasia ( J:232342 )

• E17.5 kidneys exhibit hypoplasia or agenesis

single kidney ( J:232342 )

• E17.5 kidneys exhibit hypoplasia or agenesis

nervous system

abnormal neural tube closure ( J:232342 )

• 38% of E17.5 embryos display neural tube closure defects (exencephaly and spina bifida)

spina bifida ( J:232342 )

• at E17.5

exencephaly ( J:232342 )

• at E17.5

embryo

abnormal neural tube closure ( J:232342 )

• 38% of E17.5 embryos display neural tube closure defects (exencephaly and spina bifida)

spina bifida ( J:232342 )

• at E17.5

growth/size/body

renal glomerulus cyst ( J:232342 )

• cystic glomeruli at E17.5