Phenotypes Associated with This Genotype

Genotype
MGI:5789930

• Allelic Composition: Tg(Upk2-HRAS*Q61L)5Xrw/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased urinary system tumor incidence ( J:69251 )

• 63% of mice develop superficial papillary bladder tumors from 10 to 26 months of age

renal/urinary system

increased urinary system tumor incidence ( J:69251 )

• 63% of mice develop superficial papillary bladder tumors from 10 to 26 months of age

abnormal urinary bladder urothelium morphology ( J:69251 , J:234236 )

• at 3-5 months of age, the urothelium becomes thickened to 6-7 cell layers, indicating urothelial hyperplasia (J:69251)

• urothelium becomes even more hyperplastic by 8 months of age, forming localized epithelial nodules (J:69251)

• in mice that develop bladder papillary tumors, the intervening urothelium shows simple or nodular hyperplasia and mice that dont develop tumors exhibit simple and nodular urothelial hyperplasia (J:69251)

• hyperplasia of the urothelium is seen as early as 3 months of age with increasing thickness at 12 months (J:234236)