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Phenotypes Associated with This Genotype
Genotype
MGI:5788650
Allelic
Composition
Or8a1tm39(Gnas*)Mom/Or8a1+
Genetic
Background
B6;129P2-Or8a1tm39(Gnas*)Mom/MomJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm39(Gnas*)Mom mutation (1 available); any Or8a1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
taste/olfaction
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

craniofacial
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

nervous system
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

growth/size/body
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

respiratory system
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory