Phenotypes Associated with This Genotype

Genotype
MGI:5784899

• Allelic Composition: Rassf1^tm1Gpp/Rassf1^tm1Gpp; Sav1^tm1.1Gpp/Sav1⁺
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

bile duct hyperplasia ( J:231761 )

• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice

liver/biliary system

bile duct hyperplasia ( J:231761 )

• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice

abnormal oval cell morphology ( J:231761 )

• more than 50% of mice show signs of oval cell hyperplasia

increased liver tumor incidence ( J:231761 )

• 90% of mice develop liver tumors

increased hepatoblastoma incidence ( J:231761 )

• 2.6% of mice exhibit hepatoblastoma

increased hepatocellular carcinoma incidence ( J:231761 )

• 77% of mice exhibit hepatocellular carcinoma

• 23.1% of mice exhibit mixed hepatocellular carcinoma

increased liver adenoma incidence ( J:231761 )

• 79.5% of mice exhibit hepatocellular adenoma

• 38.5% of mice exhibit mixed hepatocellular adenoma

neoplasm

increased liver tumor incidence ( J:231761 )

• 90% of mice develop liver tumors

increased hepatoblastoma incidence ( J:231761 )

• 2.6% of mice exhibit hepatoblastoma

increased hepatocellular carcinoma incidence ( J:231761 )

• 77% of mice exhibit hepatocellular carcinoma

• 23.1% of mice exhibit mixed hepatocellular carcinoma

increased liver adenoma incidence ( J:231761 )

• 79.5% of mice exhibit hepatocellular adenoma

• 38.5% of mice exhibit mixed hepatocellular adenoma