Phenotypes Associated with This Genotype

Genotype
MGI:5784731

• Allelic Composition: Arid1a^tm1.1Mag/Arid1a^tm1.1Mag; Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:231470 )

• shortened outflow tracts

abnormal conotruncus septation ( J:231470 )

• cardiac outflow tracts of E11.5 embryos show no evidence of conotruncal septation

cellular

abnormal neural crest cell migration ( J:231470 )

• fewer neural crest cells are seen in post-otic and circumpharyngeal streams of E10.5 embryos

abnormal cardiac neural crest cell migration ( J:231470 )

• the depth of cardiac outflow tract penetration by neural crest cells is reduced and elongation of the outflow tract apparatus is truncated in E10.5 embryos, resulting in shortened outflow tracts

embryo

abnormal neural crest cell migration ( J:231470 )

• fewer neural crest cells are seen in post-otic and circumpharyngeal streams of E10.5 embryos

abnormal cardiac neural crest cell migration ( J:231470 )

• the depth of cardiac outflow tract penetration by neural crest cells is reduced and elongation of the outflow tract apparatus is truncated in E10.5 embryos, resulting in shortened outflow tracts