Phenotypes Associated with This Genotype

Genotype
MGI:5781649

• Allelic Composition: Kdm4b^{tm1a(EUCOMM)Wtsi}/Kdm4b⁺
• Genetic Background: B6Dnk;B6Brd;B6N-Tyr^c-Brd Kdm4b^{tm1a(EUCOMM)Wtsi}/WtsiH
• Cell Lines: EPD0070_4_E10

Data Sources

IMPC Data for Kdm4b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:175295 )

IMPC - WTSI

nervous system

abnormal brain size ( J:302280 )

♂ • total brain area is reduced by 13.8%

enlarged lateral ventricles ( J:302280 )

♂ • lateral ventricles are enlarged in size by 92%

absent corpus callosum ( J:302280 )

♂ • corpus callosum agenesis

decreased dentate gyrus size ( J:302280 )

♂ • dentate gyrus of the hippocampus is smaller

growth/size/body

increased body length ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:175295 )

IMPC - WTSI

decreased circulating total protein level ( J:175295 )

IMPC - WTSI